Jul 31, 2017 HOW to kill pain? Mechanism of Nsaids. Learn more about Andrographis uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Andrographis. Arthritis pain is incurable but can be treated with a range of drugs, including NSAIDS such as aspirin, ibuprofen or naproxen; acetaminophen; or the newer drugs called COX-2 inhibitors. NSAIDS work very well but damage the stomach and intestine. They are blamed for 16,500 deaths a year in the United States alone, Graham said.
Responses (2)
The major side effects of NSAIDs are related to their effects on the stomach and bowels (gastrointestinal system). Some 10%-50% of patients are unable to tolerate NSAID treatment because of side effects, including abdominal pain, diarrhea, and upset stomach. Approximately 15% of patients on long-term NSAID treatment develop a peptic ulcer (ulceration of the stomach or duodenum). Even though many of these patients with ulcers do not have symptoms and are unaware of their ulcers, they are at risk of developing serious ulcer complications such as bleeding or perforation of the stomach.
Common side effects of NSAIDs may include the following:
Dizziness Headache Nausea Diarrhea Excess gas Constipation Extreme weakness or fatigue Dry mouth
Serious side effects of NSAIDs may include the following: Allergic reaction, such as difficulty breathing, hives, swelling of the lips, tongue or face Muscle cramps, numbness or tingling Rapid weight gain Black, bloody or tarry stools Bloody urine or bloody vomit Decreased hearing or ringing in the ears (also called tinnitus) Jaundice (the yellowing of the skin and the whites of the eyes) Abdominal cramping Heartburn Indigestion
Call your doctor as soon as possible if your side effects become severe.
Inactive5 Apr 2012
Suzanne's answer covers it it all, but I also get extreme pain in my stomach when I try to take any of them which leads to her list of tummy issues.
Inactive3 Apr 2012
For some people, NSAID's put them to sleep, and they cannot function when taking them. I'm not sure if that is even listed as a side effect, but I know several people who simply can't function from sleepiness.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Similar Questions
Is it common for Suboxone to cause side effects that include severe abdominal cramping?
Updated 4 Dec 2019 • 5 answers
What are some of the common side effects of neurotin?
Updated 22 Jan 2013 • 2 answers
Accutane - What are the most common side effects in men?
Fixed Dmg Reaction To Nsaids For Cancer
Updated 8 Oct 2013 • 2 answers
What are the common side effects using cumadin?
Updated 3 Oct 2014 • 1 answer
What are the common side effects of antibiotics?
Updated 13 Sep 2018 • 1 answerFAQ by Drugs.com
NSAIDs work by blocking the production of prostaglandins, chemicals in the body that cause pain and inflammation.
Non-steroidal anti-inflammatory drugs, or NSAIDs, are medicines that relieve pain and reduce inflammation.
They're used to treat a variety of conditions, including:
Osteoarthritis
Tendonitis
Muscle aches
Tooth pain
Backaches
Gout pain
Bursitis
Fever
Aches caused by the common cold
Prevention of certain cancers and heart disease
The drugs work by blocking the production of prostaglandins, chemicals in the body that cause pain and inflammation.
Aspirin was the first NSAID, made in 1897 when German chemist Felix Hoffman and the Bayer Company converted salicylic acid into acetylsalicylic acid.
However, the key ingredient in aspirin — white willow bark — has been used since ancient times.
NSAIDs are available in both prescription and over-the-counter (OTC) forms.
Prescription NSAIDs
Prescription NSAIDs include:
Celecoxib (Celebrex)
Diclofenac (Voltaren)
Diflunisal (Dolobid)
Etodolac (Lodine)
Fenoprofen (Nalfon)
Flurbiprofen (Ansaid)
Ibuprofen (Motrin)
Indomethacin (Indocin)
Ketoprofen (Orudis)
Ketorolac tromethamine (Toradol)
Meclofenamate sodium (Meclomen, Ponstel)
Mefenamic acid meloxicam (Mobic)
Nabumetone (Relafen)
Naproxen sodium (Anaprox)
Oxaprozin (Daypro)
Phenylbutazone (Butazolidin)
Piroxicam (Feldene)
Sulindac (Clinoril)
Tolmetin (Tolectin)
Salicylate (Trilisate Disalcid)
OTC NSAIDs
NSAIDs available without a prescription include:
Ibuprofen (Motrin, Advil, Nuprin, Medipren)
Aspirin (Bayer, Excedrin, Bufferin)
Naproxen sodium (Aleve)
Ketoprofen (Orudis KT)
NSAID Risks
NSAIDs can cause severe or life-threatening gastrointestinal (GI) bleeding and ulcers in some people.
NSAIDs have also been linked to a higher risk of strokes, heart attacks, and heart-related deaths, especially when used for a long period of time.
Additionally, the drugs can worsen high blood pressure, and may cause kidney damage in people over 60 years of age.
Tell your doctor if you have the following conditions before taking an NSAID:
A history of kidney or liver disease
Asthma
A history of ulcers, GI bleeding, Crohn's disease, ulcerative colitis, or gastroesophageal reflux disease (GERD)
Researchers have found that a type of NSAID known as COX-2 inhibitors (such as Celebrex) are less likely to cause GI bleeding and pain.
Tell your physician about all other medicines, recreational drugs, and supplements you're taking while on NSAIDs.
Because different medications — such as combination drugs used to treat the symptoms of colds or flu — may contain different types of NSAIDs, be aware when taking these drugs to avoid the risks of serious side effects or overdose.
NSAID Side Effects
Some common side effects of NSAIDs include:
Gas
Bloating
Heartburn
Stomach pain
Nausea
Vomiting, diarrhea, or constipation
Mild headache
Dizziness
Fixed Dmg Reaction To Nsaids Side Effects
NSAIDs can cause serious side effects. Tell your doctor right away if you experience any of the following:
Swelling of the mouth, face, lips, tongue, ankles, feet, lower legs, hands, or eye area
Ringing in the ears (tinnitus)
Itching
Severe rash or hives
Red, peeling skin
Unexplained bruising and bleeding
Unusual weight gain
Stools that are bloody, black, or tarry
Bloody or cloudy urine
Blurred vision
Severe stomach pain
Vomit that looks like coffee grounds
Wheezing, trouble breathing, or unusual cough
Chest pain or fast heartbeat
Flu-like symptoms
Extreme fatigue
Yellowing of the eyes or skin (jaundice)
Sensitivity to light
NSAIDs and Pregnancy
The use of NSAIDs during pregnancy is somewhat controversial.
NSAID use during the third trimester of pregnancy is generally not recommended because of an increased risk of complications in a newborn baby.
There is also some evidence that suggests using prescription-strength NSAIDs during the first half of pregnancy may increase the risk of miscarriage.
In 2015, the Food and Drug Administration (FDA) issued the following statement regarding the use of NSAIDs and other pain medications during pregnancy:
'Pregnant women should always consult with their healthcare professional before taking any prescription or OTC medicine. Women taking pain medicines who are considering becoming pregnant should also consult with their healthcare professionals to discuss the risks and benefits of pain medicine use.'
NSAIDs are generally considered safe to use during breastfeeding.
NSAIDs for Dogs
Some NSAIDs are approved for managing pain in dogs.
They're often used in animals with arthritis or those that have just had surgery.
Fixed Dmg Reaction To Nsaids Side Effects
NSAIDs for dogs include:
Carprofen (Novox or Rimadyl)
Deracoxib (Deramaxx)
Etodolac (Etogesic)
Firocoxib (Previcox)
Meloxicam (Metacam)
Tepoxalin (Zubrin)
These medicines are usually safe for dogs, but they have risks and may cause liver, kidney, or digestive problems.
Fixed Dmg Reaction To Nsaids Drugs
Talk to your veterinarian before giving your dog an NSAID.